Specially, something as simple as fretting the same string alternately with my index and ring fingers has proven challenging. It’s as if my hand is screaming at me that it’s not a natural motion and doesn’t want to cooperate. I’ve experienced discomfort in my left hand for years now and whatever is going on in there might be contributing to my fretting woes possibly. Maybe it’s a matter of continuing to use muscles, tendons, and ligaments that I normally don’t use in that way.